What kind of anemia does Thalassemia cause?
HYPOCHROMIC MICROCYTIC ANEMIA
- looks like Iron Xu but does not respond to Iron supplementation
What kinds of cells will you see in Thalassemia? **
Teardrop, Basophilic Stippling, Target
What kind of cells will you see in Hemolytic Anemia? **
Bite Cell, Heinz Bodies
What type of anemia will you see in Iron Xu and what will you see in their esophagus?
MICROCYTIC HYPOCHROMIC
- Plummer Vinson (webs)
What cell line is affected in MM?
Plasma cell overproduction - CA
Bence Jones proteins are seen in what Dz?
MM
MC leukemia and CA in children is?
ALL, Acute Lymphoblastic Leukemia
- can cure w Tx
MC leukemia in adults **
AML, Acute Myeloblastic Leukemia
characteristic histo finding in AML **
AUER RODS are clumps of azurophilic granular material that form elongated needles seen in the cytoplasm of leukemic blasts.
What leukemia may include any cell line? **
CML, chronic myelogenous leukemia
Philadelphia Chromosome seen in which leukemia? **
CML
What cells are affected in CLL, chronic lymphocytic leukemia?
B-cells
- well differentiated
What is the most common leukemia?
CLL - see in older pts
Vit K dependent clotting factors
2,7,9,10, protein C
Prothrombin Activators
10, 5
Poiseuille’s Equation
Resistence in BV = (viscosity)(length of BV)8/radius
Hemophilia A caused by Xu of what factor?
8 “aaaaeight” - only in males
Hemophilia B caused by Xu of what factor?
9 - only in males
VWF xu caused problems bc…
it activates 8, so if xu, 8 is not activated
Thrombocytopenia: what is it? and what causes it?
- immune, decreased production, increased use (ex. DIC)
What is Anasarca?
generalized edema vs “dependent edema”
Hydrostatic moves fluid in or out?
out
What cell is affected in Burkitt’s Lymphoma?
What is pathognomonic for Hodgkin’s Lymphoma?
Reed-Sternberg Cell