CCLE 2 FINALSSSS

Question 1

1. Which of the following best describes hypersensitivity?
   A. Immune tolerance
   B. Excessive immune response
   C. Normal immune reaction
   D. Lack of immune response

Answer 1

Answer: B

Question 2

2. Hypersensitivity is an inappropriate or exaggerated response to:
   A. Bacteria only
   B. Self-antigens only
   C. A foreign antigen
   D. External temperature

Answer 2

Answer: C

Question 3

3. Who classified hypersensitivity into four types?
   A. Jenner
   B. Coombs and Gell
   C. Pasteur
   D. Koch

Answer 3

Answer: B

Question 4

4. Which of the following is not one of the four types of hypersensitivity?
   A. Type I
   B. Type II
   C. Type V
   D. Type IV

Answer 4

Answer: C

Question 5

5. Type I hypersensitivity is also known as:
   A. Cytotoxic reaction
   B. Delayed type
   C. Immediate hypersensitivity
   D. Immune complex-mediated

Answer 5

Answer: C

Question 6

6. Which immunoglobulin is involved in Type I hypersensitivity?
   A. IgA
   B. IgM
   C. IgG
   D. IgE

Answer 6

Answer: D

Question 7

7. Mast cells and basophils are sensitized by which antibody?
   A. IgA
   B. IgE
   C. IgM
   D. IgD

Answer 7

Answer: B

Question 8

8. Which cells release histamine in Type I reactions?
   A. Neutrophils
   B. Eosinophils
   C. Mast cells
   D. Macrophages

Answer 8

Answer: C

Question 9

9. A classic example of Type I hypersensitivity is:
   A. Serum sickness
   B. Allergic rhinitis
   C. Contact dermatitis
   D. Tuberculosis

Answer 9

Answer: B

Question 10

10. Which type of hypersensitivity is cytotoxic?
    A. Type I
    B. Type II
    C. Type III
    D. Type IV

Answer 10

Answer: B

Question 11

11. In Type II hypersensitivity, the antibodies involved are:
    A. IgE only
    B. IgG and IgM
    C. IgA
    D. IgD

Answer 11

Answer: B

Question 12

12. Hemolytic disease of the newborn is an example of:
    A. Type III
    B. Type IV
    C. Type I
    D. Type II

Answer 12

Answer: D

Question 13

13. Which antigen-antibody complex causes tissue damage in Type III hypersensitivity?
    A. Cell surface antigen
    B. Free antigen-antibody complex
    C. Self-antigen
    D. None

Answer 13

Answer: B

Question 14

14. Serum sickness is classified under:
    A. Type I
    B. Type II
    C. Type III
    D. Type IV

Answer 14

Answer: C

Question 15

15. Arthus reaction is an example of:
    A. Type I
    B. Type II
    C. Type III
    D. Type IV

Answer 15

Answer: C

Question 16

16. Type IV hypersensitivity is:
    A. Immediate
    B. Antibody mediated
    C. T-cell mediated
    D. IgE mediated

Answer 16

Answer: C

Question 17

17. Delayed type hypersensitivity takes how many hours to develop?
    A. 1–2 hours
    B. 4–6 hours
    C. 24–48 hours
    D. 10 minutes

Answer 17

Answer: C

Question 18

18. Which type involves granuloma formation?
    A. Type I
    B. Type II
    C. Type III
    D. Type IV

Answer 18

Answer: D

Question 19

19. Contact dermatitis falls under which type?
    A. Type I
    B. Type IV
    C. Type II
    D. Type III

Answer 19

Answer: B

Question 20

20. Which cell type is predominantly responsible for Type IV reactions?
    A. B cells
    B. T helper cells
    C. Mast cells
    D. Basophils

Answer 20

Answer: B

Question 21

21. Which chemical mediator is stored in granules of mast cells?
    A. Serotonin
    B. Histamine
    C. Leukotrienes
    D. Prostaglandins

Answer 21

Answer: B

Question 22

22. Anaphylaxis is a feature of which hypersensitivity type?
    A. Type I
    B. Type II
    C. Type III
    D. Type IV

Answer 22

Answer: A

Question 23

23. Autoimmune hemolytic anemia is an example of:
    A. Type I
    B. Type II
    C. Type III
    D. Type IV

Answer 23

Answer: B

Question 24

24. In Type III reactions, complexes are deposited in:
    A. Nerves
    B. Lungs
    C. Blood vessels
    D. Muscles

Answer 24

Answer: C

Question 25

25. Allergic asthma is classified as: A. Type I B. Type II C. Type III D. Type IV

Answer 25

Answer: A

Question 26

26. Which hypersensitivity is antibody-independent? A. Type I B. Type II C. Type III D. Type IV

Answer 26

Answer: D

Question 27

27. Tuberculin test is an example of: A. Type I B. Type II C. Type III D. Type IV

Answer 27

Answer: D

Question 28

28. The earliest known classification of hypersensitivity was in: A. 1921 B. 1936 C. 1953 D. 1965

Answer 28

Answer: B

Question 29

29. Coombs and Gell classification was developed in: A. 1953 B. 1963 C. 1970 D. 1942

Answer 29

Answer: A

Question 30

30. Type I reaction is also known as: A. Delayed B. Anaphylactic C. Complement-mediated D. Arthus reaction

Answer 30

Answer: B

Question 31

31. The term “anaphylaxis” was coined by: A. Pasteur B. Richet and Portier C. Gell and Coombs D. Jenner

Answer 31

Answer: B

Question 32

32. Anaphylaxis involves which organ systems? A. Respiratory and cardiovascular B. Skeletal C. Endocrine D. Nervous

Answer 32

Answer: A

Question 33

33. Hay fever is an example of: A. Type II B. Type IV C. Type I D. Type III

Answer 33

Answer: C

Question 34

34. Urticaria is another term for: A. Anemia B. Fever C. Hives D. Bruising

Answer 34

Answer: C

Question 35

35. Autoantibodies against thyroid cells in Graves’ disease are an example of: A. Type II B. Type IV C. Type III D. Type I

Answer 35

Answer: A

Question 36

36. Cytotoxic hypersensitivity targets: A. Host cells B. Allergens C. Foreign DNA D. Pathogens only

Answer 36

Answer: A

Question 37

37. All of the following are examples of Type III hypersensitivity except: A. Arthus reaction B. Serum sickness C. Rheumatoid arthritis D. Contact dermatitis

Answer 37

Answer: D

Question 38

38. What leads to tissue damage in Type IV hypersensitivity? A. Antibody binding B. Complement activation C. T cell-mediated cytotoxicity D. IgE reaction

Answer 38

Answer: C

Question 39

39. All of the following hypersensitivity reactions are antibody mediated except: A. Type I B. Type II C. Type III D. Type IV

Answer 39

Answer: D

Question 40

40. Which hypersensitivity can be tested with a skin patch test? A. Type I B. Type II C. Type III D. Type IV

Answer 40

Answer: D

Question 41

41. Which cytokine is important in Type IV hypersensitivity? A. IL-1 B. TNF-α C. IFN-γ D. IL-10

Answer 41

Answer: C

Question 42

42. Which of the following is an example of local anaphylaxis? A. Bronchial asthma B. Serum sickness C. Systemic lupus D. Tuberculosis

Answer 42

Answer: A

Question 43

43. An Arthus reaction occurs after: A. Initial sensitization B. Subsequent injection of antigen C. First exposure D. Infection

Answer 43

Answer: B

Question 44

44. Which immunoglobulin causes allergic symptoms in Type I? A. IgA B. IgM C. IgG D. IgE

Answer 44

Answer: D

Question 45

45. In Type II, antibody binds to antigen on: A. Food particles B. Tissue cells C. Mast cells D. Environmental allergens

Answer 45

Answer: B

Question 46

46. Desensitization therapy is used in: A. Type II B. Type III C. Type I D. Type IV

Answer 46

Answer: C

Question 47

47. Contact with poison ivy causes: A. Type I B. Type II C. Type III D. Type IV

Answer 47

Answer: D

Question 48

48. Farmer’s lung is a result of: A. Type I B. Type II C. Type III D. Type IV

Answer 48

Answer: C

Question 49

49. Which type of hypersensitivity is involved in graft rejection? A. Type I B. Type II C. Type III D. Type IV

Answer 49

Answer: D