Is defined as an unpleasant sensory and emotional experience associated with actual or potential tissue damage or described in terms of such damage.
Pain
Stimulation of the skin evokes nervous impulses transmitted by three systems in the spinal cord (substantia gelatinosa, dorsal column fibers, central transmission cells) that influence nociceptive impulses.
Gate Control Theory
All pain results from a signal cascade traveling through the peripheral to central nervous system for processing.
Physiology of Pain
Fast sharp pain is carried by
A-delta fibers
Slow burning chronic pain is carried by
Unmyelinated C fibers
Harmful, poisonous, or very unpleasant stimuli that initiate nociception.
Noxious Stimuli
Physiologic process by which information about tissue damage is communicated to the CNS.
Nociception
Conversion of a noxious mechanical, thermal, or chemical stimulus into an electrical signal (action potential).
Transduction
Process by which pain signals are relayed from the periphery to the spinal cord and then to the brain.
Transmission
Occurs when pain is recognized, defined, and assigned meaning by the individual experiencing it.
Perception
Activation of descending pathways that exert inhibitory or facilitatory effects on pain transmission.
Modulation
Specialized receptors in tissue injury initiating pain transmission.
Nociceptors
Tissue injury triggers mast cell degranulation, histamine release, chemotactic agents, and infiltration by neutrophils and eosinophils.
Inflammatory Response
Endogenous cytokines that suppress pain induction, acting as mediators.
Endorphins
Sudden, temporary, localized, lasting less than 3 months with an identifiable cause.
Acute Pain
Prolonged, ongoing pain, often without an identifiable cause, may arise from an acute situation.
Chronic Pain
Pain perceived distant from the site of stimulus due to visceral fibers synapsing near other sensory fibers in the spinal cord.
Referred Pain
Pain occurring between doses of analgesia.
Breakthrough Pain
Pain triggered by activity, procedures, or dressings, predictable and preventable with prior analgesia.
Incident Pain
Pain from brain or spinal cord lesions causing spontaneous high-frequency impulses.
Central Pain
Common in advanced cancer, mixture of nociceptive and neuropathic pain with acute, persistent, breakthrough, and incident features.
Cancer Pain
Pain felt in amputated or removed body parts, often resembling pre-injury pain.
Phantom Pain
Point at which neurochemicals reach the brain, causing conscious awareness of pain.
Pain Threshold
Amount of pain a person endures after reaching threshold.
Pain Tolerance