What is the smallest unit that carries out the characteristic functions of life?
the cell
What are the two internal elements of the cell?
nucleus and cytoplasm
What are the two parts of the cell’s cytoplasm?
1) formed, insoluble elements like organelles
2) cytosol, or the aqueous phase and dissolved molecules
What are the boundaries that define compartments and regulate the flow of molecules?
membranes
What is the basic framework of a membrane? What are other components included in the framework?
phospholipid bilayer
cholesterol
glycolipids
sphingomyelin
What are membrane proteins and what are their functions?
proteins embedded or associated with the phospholipid bilayer
ion channels, ion pumps, hormone receptors (transmembrane proteins)
When cut in cross section and viewed with a transmission electron microscope, what is the characteristic structure of a membrane? What composes the structure?
trilaminar (three-layered)
two electron dense lines border with a less dense central zone
When cut in cross section and viewed with a transmission electron microscope, what is the characteristic structure of an epithelial membrane? What composes the structure?
multiple layers of different cell types
-epithelial cells
-basal lamia
-reticular lamina (lamia fibroreticularis)
What are the components making up the basement mebrane? Which components are translucent? Electron dense?
-lamina densa (central and electron dense)
-lamina lucida (top and translucent)
lamina fibroreticularis (bottom and translucent)
What is a glycocalyx?
when a membrane has abundant chains of sugars attached to membrane proteins, and these sugars can be seen microscopically
Where are proteins synthesized? What are proteins composed of?
ribosomes
amino acid sequences translated from mRNA
What are ribosomes composed of?
ribosomal RNA (rRNA) and proteins
What are heterochromatin?
condensed DNA and proteins in the interphase nucleus
What are euchromatin?
dispersed DNA and proteins in the interphase nucleus
Where is the site of synthesis of most rRNA?
the nucleolus
What differentiates rough endoplasmic reticulum from smooth endoplasmic reticulum?
rough endoplasmic reticulum has ribosomes attached to the membrane, smooth has no attachments
What happens to proteins synthesized on the rough ER? What gets added to the proteins to synthesize them?
packaged into granules and/or exported out of the cell
peptides that passed into the lumen of the ER and sugars to create glycoproteins
How do secretory granules release their contents?
exocytosis
membrane of the granule fuses with the plasma membrane and releases contents into the extracellular space
What is the term for membrane-bound organelles that that contain hydrolytic enzymes with acid pH optima? What do they do?
lysosomes
degrade large molecules to smaller ones
How are extracellular molecules brought into contact with target molecules? Intracellular?
endocytosis
autophagy
Lysosomes that have not been fused to molecules via membrane attachment are termed…
primary
Lysosomes that have been fused to molecules via membrane attachment are termed…
secondary
Which type of endoplasmic reticulum is active in protein synthesis?
rough ER
What are the functions of smooth ER?
phospholipid, cholesterol synthesis, detoxification of drugs, and secrete steroids