CH

Question 1

Definition of CH

Answer 1

Clonal Haematopoiesis
* Clonal proliferation of HSC & progenitors
* Any cause

Question 2

Definition of ARCH

Answer 2

Age-related CH
* Aging and CH
* No cytopenias/haem malignancy

Question 3

Definition of CHIP

Answer 3

Clonal hematopoiesis of indeterminate potential
* CH and somatic mut (VAF>2%)
* No cytopenias/haem malignancy

Question 4

Definition of CCUS

Answer 4

Clonal cytopenia of undetermined significance
* CH and somatic mut (VAF>2%)
* Cytopenia (persistent and unexplained)
* No haem malignancy

Question 5

Definition of ICUS

Answer 5

Idiopathic cytopenias of undetermined significance
* Cytopenia (persistent and unexplained)
* No mutation/haem malignancy