1. Acute basophilic leukaemia 2. t(6;9) 3. AML t(9;22) 4. CML-BP 5. Mast cell leukaemia

DDx for CD19/CD10 Positive B-cell neoplasms (CD5-) 6

1. B-ALL 2. Haematogones 3. FL 4. BL 5. DLBCL 6. MM

DDx for CD19/CD5 Positive B-cell neoplasms (CD10-) 4

1. CLL 2. MCL 3. B-PLL (SBLwPN) 4. 5% of DLBCL

DDx for villous lymphocytes 5

1. HCL 2. SMZL 3. HCLv 4. BPLL 5. SDRPL

1. HL 2. NLP HL and TCHR LBCL 3. EBV+ DLBCL 4. Peripheral T, NOS 5. Anaplastic large cells Lymphoma 6. 1' DLBCL of CNS 7. 1' mediastinal LBCL 8. 1' Effusion lymphoma Non neoplastic: Megs/Carcinoma

DDx Flashcards by Shaun Grobler

DDx for AML with Dysplasia

AML t(6;9)
MECOM
AML-MR

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DDx for AML with Monocytoid appearance (M4/M5)

NPM1
KMT2A (adults)
APL (microgranular)
NUP98

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DDx for AML with M7 fts

t(1;22)
NUP98
MECOM
KMT2A (kids)
CBFa1::GLIS (RAM IMPT)

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DDx for Basophilia

Acute basophilic leukaemia
t(6;9)
AML t(9;22)
CML-BP
Mast cell leukaemia

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Differential diagnosis of Eosinophilia (9)

Reactive (Drugs, Allergy/Infection, Solid tumour/LPD)
M/L with TK mutation
CML
AML inv16
Mastocytosis
MPN/Overlap
B-ALL t(5;14)
L-HES / M-HES
CEL

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DDx for B-ALL with Myeloid Markers

BCR::ABL1 (CD13,CD33 and CD25)
KMT2A (CD15 and CD65)
IgH::IL3/t(5;14) (CD13, CD33 and CD123)
ETV6::RUNX1/t(12;21) (CD13, CD33)

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What is the differential diagnosis of SMZL?

CLL
Hairy cell leukemia
Mantle Cell Lymphoma
Follicular lymphoma
Lymphoplasmacytic lymphoma

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DDx for B-cell neoplasms that do not express pan B-markers

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DDx for CD19/CD10 Positive B-cell neoplasms (CD5-)

B-ALL
Haematogones
FL
BL
DLBCL
MM

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DDx for CD19/CD5 Positive B-cell neoplasms (CD10-)

CLL
MCL
B-PLL (SBLwPN)
5% of DLBCL

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DDx for CD19 Positive B-cell neoplasms (CD5 and CD10-)

HCLv
MZL (SMZL, NMZL, MALT)

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Cyclin D1 positivity

MCL

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Annexin 1 Positivity

HCL

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DDx for villous lymphocytes

HCL
SMZL
HCLv
BPLL
SDRPL

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DDx for HRS cells

HL
NLP HL and TCHR LBCL
EBV+ DLBCL
Peripheral T, NOS
Anaplastic large cells Lymphoma
1’ DLBCL of CNS
1’ mediastinal LBCL
1’ Effusion lymphoma

Non neoplastic: Megs/Carcinoma

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DDx for CD30+ lymphomas

HL, BCL(5), TCL(5)

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I. cHL

II. BCL
* Anaplastic variant of DLBCL
* ALK+ LBCL
* PBL
* 1’ effusion lymphoma
* Lymphomatoid granulomatosis

III. TCL
* ATCL
* PTCL, NOS
* ALCL
* Extranodal NK/TCL
* Enteropathy ass. TCL

CHL subtypes tend to have a male predominance, with the exception of which subtype?

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Nodular sclerosing HL
- slight female predominance

What is the expression of OCT2 and BOB1

in CHL HS cells?

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absence of the transcription factor (OCT2) and its cofactor (BOB1)

Note: EMA is also negative in most cases

How can CHL lymphoma be mistaken for ALCL

and what IHC helps differentiate the two well?

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if the CHL is rich in neopastic cells it can morphologically resemble ALCL
IHC
- CHL = PAX5 (+)
  - EMA and ALK protein (-)
- Detection of EBV (LMP1) favors CHL over ALCL as well

What is one of the most difficult d/d

with CHL to differentiate?

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DLBCL with anaplastic morphology and CD30 (+) cells
- especially if it is within the mediastinum

DDx for Intrainusoidal Growth Pattern

Study These Flashcards

TLGL
NKLGL
Hepatosplenic TCL
SMZL
SDRP Lymphoma
SBCLwPN

Presence of MYD88 mutations point to which entity instead of SMZL?

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Lymphoplasmacytic lymphoma

Note: although rarely SMZL can have this mutation.

Different causitive factors in MALT lymphoma?

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Gastric - H.Pylori
- t(18;14)
- Treatment = Eradication of H. Pylori (PPI, Clarithromycin, Amoxil/Metronidazole)
- If they do not respond = RadioTx/Chemo
Ocular - Chlamydia
Skin - B. Burgdorferi
Salivatory glands - Sjogren
Thyroid - Hashimotos

DDx for Lytic Bone Lesions

Go Shimla

Study These Flashcards

Gauchers
Osteosarcoma
Systemic mastocytosis
HL/HLH
Infections
Mets/MM
Langerhans Histiocytosis
Adult TCL

DDx for MProtein

1. PCNs 2. CLL 3. SMZL 4. LPL 5. MALT

DDx for GC B-cell Neoplasms

1. DLBCL 2. BL 3. FL

What are the clinical spectrum of neoplastic diseases associated with HTLV-1 infection?

* ATLL * LGL

What are the non-neoplastic diseases associated with HTLV-1 infection ?

* HTLV-1 associated myelopathy (tropical spastic paraparesis) * HTLV-1 associated infective dermatitis * Other HTLV-1 Inflammatory Disorders * Uveitis * Thyroiditis * Pnemonitis * Myositis

DDx of EBV+ Neoplastic conditions

1. HL 2. BL 3. DLBCL 4. PBL 5. Extranodal T/NK 6. Angioimmunoblastic T

DDx for HepC virus associated neoplasms

1. SMZL 2. LPL/WM 3. Cryoglobulinaemia

DDx for HHV8 virus associated neoplasms

1. 1' effusion lymphoma 2. Multicentric castlemans

DDx for massive splenomegaly

1. CML and MPNs 2. Malaria 3. Gauchers 4. Lymphomas * Splenic B-cell lymphomas (SDRPSBcL, SBCLwPN) * Hepatosplenic TCL 5. Infective: TB, Schistosomiasis, Hepatitis 6. Inflammatory: Sarcoidosis, RA, SLE 7. Infiltration: Gauchers, Nieman Pick, Rosai Dorfman, Amyloid 8. Sequestration: SC

If you think MDS-IB rule out...

1. AML 2. biTP53

DDx Flashcards

(34 cards)