Chap 8 Genetics

Question 1

Which structural chromosome abnormality involves a single break in each chromosome involved in the event?”
A. inversion.
B. ring chromosome formation
C. interstitial deletion
D. Balanced reciprocal translocation

Answer 1

D. Balanced reciprocal translocation

Question 2

DNA ligase IV is involved in which DNA repair process?
A. Homologous recombination (HR)
B. Base excision repair (BER)
C. Non-homologous End Joining (NHEJ)
D. Mismatch repair

Answer 2

C. Non-homologous End Joining (NHEJ)

Question 3

How is it called with a male has a X mutant of an X linked recessive inheritance disorder

Answer 3

Hemizygous

Question 4

Which of the following does NOT lead to LOSS of genetic material
a. Robertsonian translocation
b Balanced reciprocal translocation
c. Deletion
d. Ring chromosomes

Answer 4

b. Balanced reciprocal translocation

Question 5

Deletions or insertions of small groups of nucleotides within a DNA coding sequence are called
a. Point mutations
b Missense mutations
c. Chromosome mutations
d. Frameshift mutations

Answer 5

d. Frameshift mutations

Question 6

All of the following are characteristic of X-linked disorders EXCEPT:
a. Daughters of affected males are carriers of the defect
b. Females with X-linked mutant genes are described as hemizygous
c. Heterozygous females often partially express the defect
d. Most X-linked disorders are recessive
e. Sons of heterozygous females have a one in two chance of receiving the mutant gene

Answer 6

b. Females with X-linked mutant genes are described as hemizygous

Question 7

What is the mechanism for genomic imprinting?
a. Translocation
b. Point mutation
c. Paracentric inversion
d. Epigenetic modification

Answer 7

d. Epigenetic modification

Question 8

Which of the following molecules does NOT play a role in homologous recombination
a. ATM1
b. ATM2
b. BRCA1
d. PARP1

Answer 8

d. PARP1 (base excision repair)

Question 9

Which of the following does NOT lead to LOSS of genetic material
a. Robertsonian translocation
b. Balanced reciprocal translocation
c. Deletion
d. Ring chromosomes

Answer 9

b. Balanced reciprocal translocation

Question 10

Deletions or insertions of small groups of nucleotides within a DNA coding sequence are called
a. Point mutations
b. Missense mutations
c. Chromosome mutations
d. Frameshift mutations

Answer 10

d. Frameshift mutations

Question 11

How is it called when a single mutant gene lead to many end effects
a. Codominance
b. Pleiotropism
c. Genetic heterogenicity
d. Incomplete penetrance

Answer 11

b. Pleiotropism

Question 12

Which of the followings entities is NOT a type of aneuplody
a. Monosomy
b. Trisomy
c. Mosaicism
d. Pleiotropism

Answer 12

d. Pleiotropism

Question 13

Best diagnostic technique to detect unknown genomic abnormalities
a. FISH
b. PCR
C. Western blot
d. Cytogenomic array

Answer 13

d. Cytogenomic array
(SNP polymorphism genotipying)