Mediators of Redness and Warmth
Histamine, prostaglandins, bradykinin, NO
Mediators of Tumor
leukotrienes (C4, D4, E4), histamine, serotonin
Mediators of pain
leukotrienes (C4, D4, E4), histamine, serotonin
Explain Fever
Pyrogens (eg, LPS) induce macrophages to release IL-1 and TNF→ ↑ COX activity in perivascular cells of hypothalamus → ↑ PGE2→ ↑ temperature set point