Chapter 12 - Acute Phase Reactants

Question 1

Acute-phase Reactants

Answer 1

More Fish on the C

Ferritin
Fibrinogen
Serum amyloid A
Hepcidin
C-reactive protein

Question 2

What’s downregulated in inflammation?

Answer 2

Albumin and Transferrin

Question 3

What occurs to Transferrin during inflammation?

Answer 3

Internalized by macrophages to sequester iron

Question 4

What occurs to Ferritin during inflammation?

Answer 4

Sequesters iron to inhibit microbial iron scavenging

Question 5

Function of Hepcidin

Answer 5

↓ iron absorption (by degrading ferroportin) and ↓ iron release (from macrophages) → anemia of chronic disease