Chapter 14

Question 1

Hallmark of Alzheimer disease

Answer 1

Degeneration of particular cholinergic pathways (Acetylcholine)

Question 2

Used to treat conditions like: depression, schizophrenia, anxiety, and Parkinson’s disease

Answer 2

Drugs affecting the concentration of Monoamine neurotransmitters

Question 3

Has implication in the pathophysiology of schizophrenia and Parkinson’s

Answer 3

Dopamine

Question 4

3 major DA-containing pathways in the CNS

Answer 4

• nigrostriatal
• mesocortical/mesolimbic
• tuberoinfundibular

Question 5

Drug

Clonidine

Answer 5

• Antihypertensive
• alpha 2 receptor agonist (adrenergic)

Question 6

Enzyme that converts NE to Epi

Answer 6

Phenylethanolamine-N-methyltransferase

Question 7

A therapeutic target for obesity, movement disorders, schizophrenia, ADHD, and wakefulness

Answer 7

H3 receptor (Histamine)

Question 8

Orphan drug status for treatment of narcolepsy

Answer 8

Inverse agonist at the H3 receptor

Question 9

Receptor with the highest affinity for the trace amine - tyramine, beta-phenylephrine, and octopamine

Answer 9

TA1 or TAAR 1

Question 10

Drug

Morphine

Answer 10

• plant alkaloid
• selective for opioid receptor
• peptide neurotranmitter

Question 11

Drug

Marijuana

Answer 11

• stimulate appetite via activation of the CB1 receptor

Question 12

Drug

Rimonabant

Answer 12

• inverse agonist of the CB1
• anoretic
• adverse effects include suicidality and depression

Question 13

CB1 receptor agonist effects

Answer 13

• stimulate appetite
• treat nausea caused by chemotherapy
• reduce pain

Question 14

Drug

Dronabinol

Answer 14

• receptor CB1 agonist
• treat nausea caused by cancer or chemotherapy

Question 15

Drug

Nabilone

Answer 15

• CB1 receptor agonist
• reduce pain

Question 16

Drug

Baclofen

Answer 16

• skeletal muscle relaxant
• psychoactive drug GHB
• sometimes used to treat narcolepsy
• GABA agonist

Question 17

Agonist of glycine receptors

Answer 17

Taurine and beta-alanine

Question 18

When ischemia or hypoglycemia in the brain leads to a massive release and impaired reuptake of glutamate

Answer 18

Glutamate - mediated excitotoxicity

Question 19

Agent for sedation and control of convulsions

Answer 19

Benzodiazapine

Question 20

Drug

Benztropine mesylate

Answer 20

• muscarinic antagonist
• used for Parkinson disease and drug-induced extrapyramidal symptoms