Serotonin

Question 1

Synonym For:

SEROTONIN

Answer 1

5 - Hydroxytryptamine

Question 2

The highest concentrations of DA are found in the

Answer 2

Brain

Question 3

• Concentrates amines in intracellular storage vesicles (non specific amine carrier)
• it is inhibited by (ans: drug)

Answer 3

• VMAT2 (vesicular monoamine transporter)
• Reserpine

Question 4

Drug:

RESERPINE

Answer 4

• selectively inhibits VMAT2
• used as antihypertensive and antipsychotic agent

Question 5

Actively transports essential AA in the Brain

Answer 5

L-type Amino Acid Transporter 1
(LAT1)

Question 6

The rate limiting enzyme for 5-HT synthesis

Answer 6

Tryptophan hydroxylase (TPH)

Question 7

Responsible for the uptake of newly released 5HT

Answer 7

SERT
(Serotonin Transporter)

Question 8

MAO-A preferentially metabolizes ()

Answer 8

5HT and NE

Question 9

First Generation Antidepressants

Answer 9

MAO-A Inhibitors

Question 10

Preferentially metabolizes beta - phenylethylamine and benzylamine

Answer 10

MAO-B

low dose selegiline is a relatively selective inhibitor of MAO-B

DA and tryptamine are metabolized equally by both MAO-A and MAO-B