thyroid hormone replacement prototype & other meds
Levothyroxine, Liothyronine, Liotrix, Thyroid USP
thyroid hormone replacement action/purpose
Replaces T4, T3, or both
↑ metabolism, cardiac output, growth, energy
thyroid hormone replacement uses
Hypothyroidism, Myxedema coma
Goiter, cretinism
Post-thyroid surgery or radiation
thyroid hormone replacement routes
Oral daily (empty stomach AM)
IV for emergencies
thyroid hormone replacement side effects/complications
Overdose → hyperthyroid symptoms (anxiety, tachycardia, weight loss, tremors)
Long-term high dose → atrial fibrillation, osteoporosis
thyroid hormone replacement precautions/interactions
Safe in pregnancy
Caution: heart disease, elderly, diabetes
Not for obesity
↓ absorption: iron, calcium, antacids → separate by 4 hrs
↑ warfarin effect → monitor PT/INR
↑ insulin/digoxin needs
thyroid hormone replacement nursing/patient tip
Take AM, empty stomach, 30–60 min before food
Do not stop or switch brands
Lifelong therapy
Monitor TSH, T4, HR
Watch for hyperthyroid or hypothyroid signs
thyroid hormone replacement effectiveness
TSH/T4 normalize
Energy ↑, weight stabilizes, cold intolerance resolves
thyroid hormone replacement NCLEX Tip:
“Levo = Lift metabolism — take early, empty stomach, for life!”