Chapter 43: Macrolides

Question 1

Macrolides prototype & other meds:

Answer 1

Erythromycin, Azithromycin, Clarithromycin

Question 2

Macrolides purpose

Answer 2

Blocks protein synthesis → bacteriostatic, high doses bactericidal

Treats:

Penicillin-allergic infections

Strep

Whooping cough

Diphtheria

Chlamydia

Pneumonia

Question 3

Macrolides complication

Answer 3

GI upset: N/V

Prolonged QT → dysrhythmias

Ototoxicity: tinnitus, veritgo, hearing loss

Question 4

Macrolides precautions

Answer 4

Use caution in pregnancy/lactation

Avoid in liver disease

Avoid in dysrhythmias (QT issues)

Question 5

Macrolides interactions

Answer 5

↑ levels of warfarin, digoxin, antihistamines

Avoid certain antifungals/heart meds

Question 6

Macrolides how to take

Answer 6

Take on empty stomach (except azithromycin)

IV only for severe infection

Finish full course

Use backup contraception if needed

Avoid sex until STD treatment completed

Question 7

Macrolides how you know it’s working

Answer 7

fever ↓

Sore throat & cough improve

Pneumonia improves

Endocarditis labs normalize

Question 8

Macrolides NCLEX Trick

Answer 8

“MACRO = Big QT + Big GI”

Big QT: prolonged QT risk

Big GI: strong stomach upset

Also think:
“THRO” drugs can affect the THROat (strep), and cause ear (OTO) problems.