What receptor on platelets bind to vWF?
Gp1B
Platelets release ADP and calcium to bind to P2y12 on platelets to upregulate which receptor?
Gp2b/3a
Gp2b/3a receptor binds to what substance to aggregate platelets?
Fibrinogen (factor 1)
Arachidonic acid is released from platelets and cleaved to Thromboxane A2 via which enzyme?
Cyclooxygenase - same enzyme and pathway that produces prostaglandins
Bernard-Soulier syndrome pathophysiology
Gp1b deficiency which leads to low adhesion of platelets to vWF
Is Bernard Soulier syndrome corrected which Ristocetin test?
No, in order for the test to work, both vWF and Gp1b must be intact
Glanzmann Thrombasthenia pathophysiology
Gp2b3a deficiency which leads to low aggregation
Immune thrombocytopenic purpura pathophysiology
Autoimmune antibodies against the Gp2b/3a receptor. This marks the platelets for destruction by the spleen
Thrombotic microangiopathies pathophysiology for making schistocytes
Thrombotic thrombocytopenic purpura -
