Chapter 6 Allostery

Question 1

allosteric enzymes have a ____ curve

Answer 1

sigmoidal

don’t follow M-M kinetics

Question 2

do allosteric enzymes tend to have more than 1 subunit?

Answer 2

yes

Question 3

do allosteric enzymes tend to have more than 1 conformation?

Answer 3

yes, mediated by small molecule binding (modulator binding)

Question 4

activators stabilize…

Answer 4

high affinity state

Question 5

inhibitors stabilize…

Answer 5

low affinity state

Question 6

when are allosteric enzymes found in the pathway?

Answer 6

at the 1st committed step

evolution

Question 7

post-translational modification

Answer 7

covalent modification that controls activity

conformational change occurs upon adding/removing a covalently bound small molecule