collagen
A strong, fibrous protein made up mostly of glycine and proline amino acids.
hydroxyapatite
The primary crystal of bone formed from calcium and phosphorous.
trabecular or cancellous bone
Less dense bone with a lattice-like structure. Also called spongy bone
cortical bone
Dense, strong bone that surrounds trabecular bone tissue. Also called compact bone.
osteoblasts
Cells that build new bone tissue.
osteoclasts
Large cells that break down bone tissue.
osteocytes
Star-shaped cells that are the most abundant cell type in bone tissue.
bone remodeling
Process in which bone tissue is broken down and then rebuilt at the same location.
bone resorption
Process in which osteoclasts secrete hydrogen ions, which acidify the local
environment and dissolve the minerals in the bone tissue matrix.
osteoid
Bone tissue that is not mineralized.
Bone mineral density
Measurement of the amount of calcified tissue in grams per centimeter squared of bone tissue.
dual-energy X-ray absorptiometry (DEXA)
A procedure during which two X-ray beams pass through a person and calculate the amount of calcified tissue in grams per unit area of bone.
calcium
The most abundant mineral in mineralized bone tissue. Good dietary sources of calcium are dairy products and many vegetables with low oxalate content, such as kale, collard greens, and okra
parathyroid hormone (PTH)
Parathyroid hormone acts to increase calcium levels in the blood
calcitriol
The active hormone produced by vitamin D that also helps to increase and regulate blood calcium levels.
calcitonin
This hormone has the opposite effect of calcitriol and parathyroid hormone and aids in the maintenance of blood calcium levels by decreasing the calcium level as necessary.
Vitamin D
Both a vitamin and a hormone, vitamin D plays an essential role in maintaining calcium homeostasis. A deficiency in vitamin D compromises bone health.
nutritional rickets
A childhood bone disease caused by a lack of vitamin D. It is characterized by soft, weak bones that are susceptible to fracture.
osteomalacia
Similar to nutritional rickets, in adults this disease involves softening
and weakening of the bones due to a lack of vitamin D or a problem metabolizing the vitamin.
Phosphorus
A mineral that makes up a substantial part of mineralized bone tissue. The dietary sources are non-genetically-modified soy, legumes, whole grains, dairy, nuts, and seeds.
magnesium
A mineral that is part of mineralized bone tissue. The dietary sources are meat, fish, dairy products, whole grains, nuts, chocolate, and coffee
fluoride
A mineral that blocks tooth decay and is part of mineralized bone tissue. The primary dietary source is fluoridated water.
vitamin K
A vitamin that acts as a coenzyme that modifies proteins important for bone health. The dietary sources are green vegetables such as broccoli, cabbage, kale, parsley, spinach, and lettuce
osteoporosis
Excessive bone loss over time