Cholinergic DSA

Question 1

Direct acting cholinomimetics

Answer 1

• acetylcholine
• bethanechol
• carbachol
• cevimeline
• methacholine
• pilocarpine
• varenicline

Question 2

Cholinesterase inhibitors

Answer 2

Ambenonium 
Donepezil 
Echothiophate 
Edrophonium 
Galantamine 
Neostigmine 
Physostigmine 
Pyridostigmine 
Rivastigmine 
Tacrine

Question 3

Cholinesterase regenerator

Answer 3

Pralidoxime
Tolterodine
Trospium

Question 4

Drugs used for cholinergic poisoning

Answer 4

atropine (+ pralidoxime)

Cholinesterase regenerator

Question 5

Drugs used for movement disorders

Answer 5

benztropine
biperiden

Cholinesterase regenerator

Question 6

Drugs used for motion sickness

Answer 6

scopolamine

Antimuscarinic drugs

Question 7

Drugs used for GI disorders

Answer 7

Atropine
Dicyclomine
Glycopyrrolate
Hyoscyamine

Antimuscarinic drugs

Question 8

Drugs used in ophthalmology

Answer 8

Atropine
Cyclopentolate
Homatropine
Scopolamine
Tropicamide 

Antimuscarinic drugs

Question 9

Drugs used for respiratory disorders (asthma, COPD)

Answer 9

Ipratropium
Tiotropium

Antimuscarinic drugs

Question 10

Drugs used for urinary disorders

Answer 10

Darifenacin 
Fesoterodine 
Oxybutynin 
Solifenacin 
Orphenadrine 
Procyclidine 
Trihexyphenidyl 

Antimuscarinic drugs

Question 11

Ganglion blockers

Answer 11

mecamylamine

Question 12

Why do we give choline esters orally?

Answer 12

• you don’t

- they are poorly absorbed orally

Question 13

Patient presents with poisoning from eating a wild mushroom. What’s going on?

Answer 13

• muscarine is poisonous when ingested, and crosses BBB

Question 14

How do direct acting cholinergic agonists affect skeletal muscle?

Answer 14

• eventually leads to flaccid paralysis if sustained at site for too long
• ONLY nAChRs affected

Question 15

All parasympathetic cardiac actions are mediated by…

Answer 15

M2

• small agonist dose: decrease PVR, initial decrease in BP (goes back up due to baroreceptors)
• large dose: bradycardia

Question 16

What R is found in high abundance in the brain? SC?

Answer 16

a. MAChR

b. NAChR

Question 17

How long do the following AChE inhibitors last?

a. alchols
b. carbamic acid esters
c. organophosphates

Answer 17

a. 10 minutes
b. .5 to 6 hours
c. hundreds of hours