What is the first receptor in every branch of the nervous system?
-Nicotinic
What is the only nervous system that has the muscarinic receptor?
-Parasympathetic
What enzyme turns Choline and Acetyl CoA into acetylcholine?
-Choline acetyltransferase
What deactivates acetylcholine?
-acetylcholinesterase
The creation of acetylcholine is mediated by what type of action potential?
-Calcium
What hydrolizes ACH and where?
- Cholinersterase
- Synaptic cleft
What is the neurotransmitter for adrenergic neurons?
-Noreinephrine
Where does norepi bind?
- Alpha 1
- Beta 1 and 2
What 4 ways can the norepi signal be terminated?
- Reuptake
- Dillution by diffusion
- Metabolism by MAO and COMT
What are the 2 types of synthetic non-catecholamines and give an example of each.
- Indirect (ephedrine)
- Direct (Neosynepherine)
How do indirect acting symapthomimetics work? Direct acting?
- They release endogenous norepi
- They work directly on effector organs
Anticholinesterase drugs can be divided into what 2 categories?
- Tertiary amines (Physostigmine)
- Quaternary amines
What is the difference between tertiary and quaternary amine?
- Tertiary = Neutral charge, crosses BBB
- Quaternary = Positive charge, reverse NDMR
How does Anticholinesterase drugs work?
-Inhibit acetylcholinerase which results in increased acetylcholine.
How does neostigmine/pyridostigmine work?
-Carbamylates acetylcholinesterase and blocks its ability to hydrolyze acetylcholine
How does edrophonium work?
-Reversible electrostatic attachment
-
Class 1 Deck 116
-
Class 1 Deck 216
-
Class 2 Deck 132
-
Class 2 Deck 242
-
Class 3 Deck 17
-
Class 4 Deck 129
-
Class 4 Deck 244
-
Class 5 Deck 145
-
Class 5 Deck 215
-
Class 6 Deck 143
-
Class 6 Deck 227
-
Class 7 Deck 144
-
Class 7 Deck 228
-
Class 8 Deck 146
-
Class 8 Deck 242
-
Class 9 Deck 156
-
Class 10 Deck 164
-
Class 11 Deck 145
-
Class 11 Deck 243
-
Class 11 Deck 315
-
Class 12 Deck 153
-
Class 12 deck 233
-
Class 13 Deck 162
