What CV effects does hypothyroid patients have?
- Brady
- Decrease SV
- Decreased CO
Armour thyroid combine what 2 things?
-T3 and T4 (T4:T3 = 4:1)
What does armour thyroid treat?
- Hypothyroid (goiter)
- Regression of TSH tumors
What is synthroid? what is the half life?
- T4 (deionated and converted to T3)
- 7 days
What is liothyronine (cytomel)? and how does it compare to Synthroid?
- Levorotatory isomer of T3
- 2-3x more potent (rapid on off)
Liothyronine (T3) (Cytomel®) has a higher incidence of what?
-Cardio side effects
What does calcitonin do?
- released from thyroid gland
- Decreases plasma calcium
When is calcitonin useful?
-treatment of pain and complications of Paget’s
how do Propylthiouracil (PTU) and Methimazole (Tapazole®) work?
- Block synthesis of thyroid hormone
- Block T4 conversion to T3
- Only oral
When are Propylthiouracil (PTU) and Methimazole (Tapazole®) useful?
-Hyperthyroid and Storm before thyroidectomy
what are the side effects of Propylthiouracil (PTU) and Methimazole (Tapazole®)
-Granulocytopenia and agranulocytosis
how do Thiocyanate and Perchlorate work?
-Block uptake of iodine by thyroid
What is the oldest effective treatment for hyperthyroid? and how does it work?
- Iodide (Lugols solution)
- Inhibits release of thyroid hormone
What is iodide combined with to treat hyperthyroidism before thyroidectomy?
-Propanolol
How to treat thyroid storm?
- Cold crystalloids
- Sodium iodide
- Cortisol
- Propanolol
- Propylthiouracil
- Avoid ASA
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