1
Q
MOA
Clindamycin
A
Binding of 50S ribosome leading to inhibition of protein syntesis
2
Q
What is the bioavailability of Clindamycin?
A
90%
3
Q
What is clindamycin good for?
A
good tissue penetration – skin/soft tissue infections
eg diabetic foot wound
4
Q
Where is clindamycin metabolized?
A
liver
5
Q
Spectrum of activity
Clindamycin
A
Strep, Staph, Anaerobes, Sulfonamide allergy
6
Q
What is the major adverse effect of clindamycin?
A
Clostridium difficile (Pseudomembranous colitis)
Drugs - Allman
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