Drugs - Allman > Tetracyclines > Flashcards

Tetracyclines Flashcards

(8 cards)

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1
Q

MOA

Tetracyclines

A

Reversibly binds to 30S ribosomal subunit - dec protein synthesis
Bacteriostatic

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2
Q

Which tetracyclines are eliminated renally

A

tetracycline
oxytetracycline
Democlocycline

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3
Q

Which tetracyclines are eliminated hepatobiliary

A

doxycycline

minocycline

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4
Q

Adverse reactions

tetracyclines

A
  • Photosensitivity

- discoloration of developing teeth - pregnancy and children

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5
Q

What results in Fanconi-like syndrome

A

Outdated Tetracycline

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6
Q

Important drug interaction to keep in mind when using tetracyclines

A

Divalent and Trivalent cations will chelate antibiotic

Ca2+,Mg,Al, Dairy products, etc

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7
Q

Which tetracycline is used for treatment of SIADH?

A

Demeclocycline

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8
Q

Clinical uses

Tetracycline

A 
Rickettsia infections
Mycoplasma pneumo
Chlamydia
Brucellosis
vibrio cholera
Borrelia burgdorferi
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