coagulation

Question 1

what are the vitamin K dependent proteins?

Answer 1

• II
• VII
• IX
• X
• protein C and S

Question 2

difference between primary and secondary haemostasis

Answer 2

primary is the platelet plug formation

secondary is a sequence of enzymatic reaction where fibrin strands are formed
- involves proteins not cells

coagulation pathway is activated at the same time as platelet activation

Question 3

was does the antithrombin protein inhibit

Answer 3

• IIa
• Xa
• IXa

Question 4

what does protein C inhibit

Answer 4

• Va

- VIIIa

Question 5

what does TFPI inhibit

Answer 5

tissue factor

VIIa

Question 6

what is the action of vitamin K

Answer 6

is responsible for the folding of the GLA domain on the vitamin K dependent proteins. This folding allows binding to the membrane to occur and therefore activity

Question 7

vitamin K in newborns

Answer 7

• naturally new borns are deficient in vitamin K

- to reduce the possibility of hemorrhagic disease vitamin K supplements are given

Question 8

warfarin

Answer 8

is an anticoagulant drug (bleeding)

inhibits vitamin K

Question 9

define fibrinolysis and how it occurs

Answer 9

is the physiologic breaking down of clots

• plasminogen is transformed into plasmin by TPA
• plasmin is a digestive enzyme that breaks down clots e.g. insoluble fibrin to D-dimer

Question 10

D-dimer

Answer 10

can be used to measure the quantity of broken down fibrin

levels will be high in patients with thrombosis/clotting