coagulation cascade

Question 1

primary hemostasis (3)

Answer 1

1. platelets
2. vessel
3. vWF protein

Question 2

VWF and collagen

Answer 2

adhesion

Question 3

shape change

Answer 3

activation

Question 4

granule content release

Answer 4

secretion

Question 5

platalet-platelet interaction

Answer 5

aggregation

Question 6

secondary hemostasis

Answer 6

fibrin clot

Question 7

turns finibrogen to fibrin

Answer 7

thrombin

Question 8

transglutaminase

Answer 8

FXIII

Question 9

quiescent endothelium

Answer 9

• barrier function mantained
• anticoagulant, antithrombotic surface
• non-adhering surface for leukocytes s

Question 10

activated endothelium

Answer 10

• injury, infection, endothelial denudation

- activation of complement and coagulation pathways

Question 11

Tissue factor: FVIIa activates

Answer 11

1. FX

2. FIX

Question 12

thrombin activates ____which then

Answer 12

activates FXIII which then crosslinks fibrin monomers

Question 13

vit. K involved in the synthesis of

Answer 13

1. FII
2. FVII
3. IX
4. X
5. protein C
6. Protein S

Question 14

vit. k is obtained

Answer 14

it is a fat soluble vitamin obtained through green leafy vegetables and bacterial synthesis in the gut

Question 15

role of vit. K

Answer 15

conversion glutamic acid to gamma-carboxyglutamic acid (Gla)

Question 16

inhibits vit. k epoxide reductase and thus inhibits salvage of vit. k

Answer 16

warfarin

Question 17

stabilization of fibrin clot

Answer 17

FXIII, a transglutaminase activated by thrombin, stabilizes this fibrin polymer by crosslinking the fibrin strands

Question 18

FXIII is a late step and not ________

Answer 18

reflected in screening assays

Question 19

fibrinolysis

1. what is it?
2. physiologic
3. pathologic
4. release from endothelium
5. tPA converts plasminogen to ______ whcih will

Answer 19

1. breakdown of the fibrin clot
2. physiologic: wound healing and maintain blood flow
3. pathologic: hemorrhage
4. releases from endothelium: tissue plasminogen activator (tPA)
5. tPA converts plasminogen to plasmin which will cause fibrin to be degraded

Question 20

Common pathway factors:

Answer 20

fibrinogen, prothrombin(FII), FV, FX

Question 21

Intrinsic pathway factors:

Answer 21

common pathway and FVIII, FIX, FXI, and FXII

Question 22

Extrinsic pathway factors: common pathway and FVII

Answer 22

common pathway and FVII

Question 23

partial thromboplastin time is part of the (PTT)

Answer 23

intrinsic system

Question 24

prothrombin time is part of the (PT)

Answer 24

extrinsic system

Question 25

thrombin time

Answer 25

conversion of fibrinogen to fibrin clot

Question 26

are VWF and FXIII reflected in the PTT or PT?

Answer 26

nope