IMSE 311 (lec) > Complement System I > Flashcards

Complement System I Flashcards

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1
Q

Alteration of a complement (protein) in such a way that it can proceed to interact with the next component in the pathway (cascade).

[terms]

A

Complement activation

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2
Q

Utilization of complement components by the antigen-antibody complex.

[term]

A

Complement fixation

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3
Q

The dilution of a serum sample which can LYSE A PREDETERMINED PROPORTION of a sheep erythrocyte (sRBC) suspension coated with anti-sRBC antibody.

[term]

A

Hemolytic units

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4
Q

Denaturation (usually by heat) of ONE OF THE EARLY components inactivation pathway resulting in the destruction of C-hemolytic activity.

A

Complement inactivation

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5
Q

Complement system was coined by?

A

Paul Ehrlich

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6
Q

She explains the nature of complement.

A

Jules Bordet

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7
Q

Designated by numbers, symbols and trivial names.

A

Complement system

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8
Q

Orde of discovery:

A

1,2,3,4,5,6,7,8,9

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9
Q

Order of activation:

A

1,4,2,4,5,6,7,8,9

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10
Q

Thermolabile

[temp]

A

56°C for 30 minutes

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11
Q

Regain activity

[temp]

A

37°C

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12
Q

Days of activity lost at refrigerator temperature.

A

3-4 days

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13
Q

Days where it deteriorates at room temperature.

A

1-2 days

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14
Q

[7] Inactivated by:

[apecabs]

A
  1. Acid and alkalis
  2. Proteolytic enzymes
  3. Ether
  4. Chloroform
  5. Alcohol
  6. Bile salts
  7. Soap
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15
Q

Reacts best at:

[pH]

A

7.2 - 7.4

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16
Q

Reacts best at what temperature?

A

30 - 37°C

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17
Q

Preserved BEST by?

A

Lyophilization

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18
Q

[3] Phase for each of the main pathway

A
  1. Initiation
  2. Amplification
  3. Membrane Attack Complex (MAC)
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19
Q

[4] Classical pathway:

[activation proteins]

A

C1qrs, C2, C3, C4

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20
Q

[3] Lectin pathway

[activation proteins]

A

MBP, MASP, MASP2

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21
Q

[3] Alternative pathway

[activation proteins]

A
  • C3
  • Factors B and D
  • Properdin
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22
Q

[5] Lytic pathway

[activation proteins]

A

C5, C6, C7, C8, C9

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23
Q

[3] Pathways of Complement Activation

A
  1. Classical pathway
  2. Alternative pathway
  3. Lectin pathway
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24
Q

First complement pathway being studied.

[pathway]

A

Classical pathway

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25
Initiated by: Ag-Ab complex (IgM, and 2 IgG) [pathway]
Classical pathway
26
Recognition units: C1q, C1s, C1s (+ calcium) [pathway]
Classical pathway
27
Activation units: C4, C2, C3 [pathway]
Classical pathway
28
Membrane attack complex: C5, C6, C7, C8 and C9 [pathway]
Classical pathway
29
[3] Recognition units of classical pathway
C1q, C1s, and C1s (+calcium)
30
[3] Activation units of classical pathway
C2, C3, C4
31
Binds to Fc of IgM and IgG –recognizes the Fc portion of antibody. [proteins of complement system: classical pathway]
C1q
32
Activates C1s [proteins of complement system: classical pathway]
C1r
33
Cleaves C4 and C2 [proteins of complement system: classical pathway]
C1s
34
Part of C3 convertase (C4b) [proteins of complement system: classical pathway]
C4
35
Second most abundant complement component. [proteins of complement system: classical pathway]
C4
36
Binds to C4b –form C3 convertase. [proteins of complement system: classical pathway]
C2
37
Key intermediate and pivotal point in all pathways. [proteins of complement system: classical pathway]
C3
38
Most abundant complement component [proteins of complement system: classical pathway]
C3
39
Initiates membrane attack complex. [proteins of complement system: classical pathway]
C5
40
Binds C5bC6 in MAC [proteins of complement system: classical pathway]
C7
41
Starts pore formation on membrane. [proteins of complement system: classical pathway]
C8
42
Polymerizes to cause cell lysis. [proteins of complement system: classical pathway]
C9
43
Also known before as properdin pathway.
Alternative pathway
44
Originally thought to be initiated/activated by Factor P. [pathway]
Alternative pathway
45
Acts as a stabilizer for C3 convertase and C5 convertase in the presence of magnesium. [alternative pathway]
Factor P
46
Initiated by: cobra venom factor, LPS, bacterial cell wall, yeast, virally infected cells, tumor cell lines, parasite, and aggregation of IgA. [pathway]
Alternative pathway
47
It by passes C1qrs, C4 and C2. [pathway]
Alternative pathway
48
Activation starts with Native C3 (iC3) through water hydrolysis. [pathway]
Alternative pathway
49
Binds to C3b to form C3 convertase. [proteins of complement system: alternative pathway]
Factor B
50
Cleaves factor B [proteins of complement system: alternative pathway]
Factor D
51
Stabilizes C3 convertase and C5 convertase in the presence of Mg2+. [proteins of complement system: alternative pathway]
Properdin
52
Most recently describes complement pathway and most ancient pathway. [pathway]
Lectin pathway
53
Represents another means of activating complement without antibody being present. [pathway]
Lectin pathway
54
Structurally similar to those of the classical. [pathway]
Lectin pathway
55
Binds to mannose or related sugars in a calcium dependent manner to initiate this pathway. [lectin pathway]
MBL
56
This pathway provides an additional link between the innate and acquired immune response. [pathway]
Lectin pathway
57
This pathway plays an important role as a defense mechanism in infancy during the interval between the loss of maternal antibody and acquisition of a full fledged antibody response to pathogens. [pathway]
Lectin pathway
58
Binds to mannose [proteins of complement system: lectin pathway]
MBL
59
Helps cleave C4 and C2. [proteins of complement system: lectin pathway]
MASP - 1
60
Cleaves C4 and C2 [proteins of complement system: lectin pathway]
MASP - 2
61
Antibody dependent: Yes (IgM, 2IgG)
Antibody dependent
62
Stimulus: Antigen-Antibody Complexes [pathway]
Classical pathway
63
Stimulus: Binds to CRP, E. coli, Mycoplasma, Protozoa [pathway]
Classical pathway
64
Stimulus: Lipopolysaccharide Fungal Cell, Yeast, and Parasites [pathway]
Alternative pathway
65
Stimulus: Mannose and several other sugars found primarily on bacteria, some yeasts, viruses, and several parasite. [pathway]
Lectin pathway
66
Initiation unit: C1 (q,r,s) [pathway]
Classical pathway
67
Initiation unit: C3
Alternative pathway
68
Activation unit: C3 convertase and C5 convertase [pathway]
Alternative pathway
69
MAC: [alternative pathway]
C5b6789
70
Cause basophil/mast cells degranulation and smooth muscle contraction. [biologically active products of compelement activation]
Anaphylatoxin (C3a, C4a, C5a)
71
Promotes diapedesis. [biologically active products of complement activation]
Chemotactic Factor (C5a)
72
Promotes phagocytosis. [biologically active products of complement activation]
Opsonins (C3b)
73
Accumulation of body fluid. [component] [biologically active products of complement activation]
C2b (prokinin)
74
Basophil and mast cell degranulation; smooth muscle contraction. [component] [biologically active products of complement activation]
C3a, C4a (anaphylatoxin)
75
Effect: [C2b (prokinin)]
Edema
76
Effect: [C3a, C4a (Anaphylatoxin)]
Anaphylaxis
77
Controls: [C2b (prokinin)]
C1 - INH
78
Controls: [C3a, C4a (Anaphylatoxin)]
Carboxypeptidase - B (C3a - INA)
79
Opsonization; phagocyte activation [component] [biologically active products of complement activation]
C3b and its products
80
Effect: [C3b and its products]
Phagocytosis
81
Chemotaxis; attachment to other cell membrane [component] [biologically active products of complement activation]
C5b67
82
Effect: Inflammatory lysis of by stander cells [component] [biologically active products of complement activation]
C5b67
83
Controls: Protein S (MAC) [component] [biologically active products of complement activation]
C5b67
84
Dissociates C1r and C1s from C1q [protein][plasma regulatory protein for complement]
C1 inhibitor (C1INH)
85
Cleaves C3b and C4b [protein][plasma regulatory protein for complement]
Factor I
86
Cofactor with I to inactivate C3b; prevents binding of B to C3b [protein][plasma regulatory protein for complement]
Factor H
87
Acts as a cofactor with I to INACTIVATE C4b. [protein][plasma regulatory protein for complement]
C4 binding protein
88
Acts as a cofactor with I and BINDS C3b. [protein][plasma regulatory protein for complement]
CR1 (CD35)
89
Accelerates dissociation of C3 convertase. [protein][plasma regulatory protein for complement]
Decay Accelerating Factor (CD55)
90
Inhibits MAC through binding with CD8 to prevent insertion of CD9. [protein][plasma regulatory protein for complement]
Membrane Inhibitor of Reactive Lysis (MIRL/Cd59)
91
Prevents attachment of C5b67 complex to cell membrane. [protein][plasma regulatory protein for complement]
S protein (vitronectin)
IMSE 311 (lec)
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