compounding methods for semisolid preparations

Question 1

incorporation

Answer 1

mixnig one semisolid formualtion into antoher

• > geometric dilution
• > levigating (slab with spatula)
• > trituartion

Question 2

fusion

Answer 2

components melting together, then cooled with constant stirring until congealsed

*for emulsions prep: heat oil phase and water phase seperately, then add water phase to oil phase and mix till congealed

Question 3

combining fusiona nd incorportation

Answer 3

used for emulsion type f creams or suspension type of ointments

• fusion first

- incorporation 2nd

Question 4

Indicate the method of preparation for the following formulations:

Rx (For 100g)

Curcumin 0.5g

White petrolatum 99.5g

Answer 4

Method: Levigate the curcumin with a small proportion of the white petrolatum. Using geometric dilution incorporate the white petrolatum and thoroughly mix.

Question 5

Indicate the method of preparation for the following formulations:

Cocaine hydrochloride 1.5 g

Phenol crystals 3g

Tannic acid 10g

Hydrous lanolin 40 g

White petrolatum qs 100g

Answer 5

1. Pulverize the phenol crystals into a fine powder.
2. Add about 35 g of white petrolatum and mix well.
3. Add the lanolin to the phenol:white petrolatum mixture.
4. Mix the tannic acid with 4 mL of purified water (solubility 2.9g/mL).
5. Incorporate the tannic acid solution into the ointment.
6. Dissolve the cocaine hydrochloride in 1 mL of water as possible (solubility 2.5g/mL).
7. Incorporate the cocaine hydrochloride solution into the ointment.
8. Add sufficient white petrolatum to make 100 g and mix well.

Question 6

Indicate the method of preparation for the following formulations:

Carbopol 934 0.24%

Propylene glycol 16.7 %

Methylparaben 0.015%

Sodium hydroxide, qs

Purified water, qs ad 100%

Answer 6

Method:

1. Dissolve methylparaben and disperse Carbopol 934 in about 80g of purified water (if making 100g)
2. Add propylene glycol
3. Neutralize with sodium hydroxide until pH about 7
4. make up to 100 g

Question 7

Indicate the method of preparation for the following formulations:

Cetyl esters wax 125g

White wax 120g

Mineral oil 560g

Sodium borate 5g

Water 190ml

Answer 7

Method:

1. Melt together cetyl esters wax, white wax and mineral oil at about 70C
2. Dissolve sodium borate in water at 70C
3. Mix aqueous phase into oil phase while mixing and keep mixing until congealed

Question 8

Indicate the method of preparation for the following formulations:

Rx (For 100g)

Peruvian balsam: 12g

Levigating agent: 12g

Sulfur ointment: 76G

Sulfur Ointment

Precipitated sulfur: 10g

Liquid petrolatum: 10g

White ointment: 80g (white wax 5g and 95g white petrolatum)

Answer 8

1. Mix the Peruvian balsam with castor oil as the levigating agent 2. Incorporate the sulfur ointment by geometric dilution
2. Mix until uniform

Sulfur ointment is prepared :
1. Levigate the precipitated sulfur with the liquid petrolatum to a smooth paste. 2. Incorporate the white ointment and mix until uniform

White Ointment is prepared:
1. Melt the white wax and white petrolatum together until liquefied at around 60-70C 3. Mix until congealed and cooled to room temperature

Question 9

Indicate the method of preparation for the following formulations:

Zinc oxide 250g

Starch 250g

White petrolatum 500g

Answer 9

1. Mix zinc oxide and starch
2. Levigate with white petrolatum by geometric dilution to form a smooth paste

Question 10

Indicate the method of preparation for the following formulations:

Rx
Sodium lauryl sulfate 10g

Propylene glycol 120g

Stearyl alcohol 250g

White petrolatum 250g

Purified Water 370g

Methyl paraben 0.25g

Propyl paraben 0.15g

Answer 10

1. Prepare water phase:
   
   • dissolve sodium lauryl sulfate and methyl paraben in water at 70C - add propylene glycol
2. Prepare oil phase:
   
   • melt together stearyl alcohol and white petrolatum at 70C
   • add propyl paraben, mix until dissolved
3. Add water phase to oil phase while mixing, continue mixing until congealed and cooled to room temperature

Question 11

Indicate the method of preparation for the following formulations:

Cholesterol 30g

Cottonseed oil 30g

White petrolatum 940g

Answer 11

Method:

1. Melt all ingredients together at around 70C
2. mix until congealed and cooled to room temperature