Pharmacology > Distribution > Flashcards

Distribution Flashcards

(18 cards)

Study These Flashcards
1
Q

Distribution is

A

When drugs leave blood and enter extravasc. fluids and tissues

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Rate limiting step in distribution is

A

Blood flow

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What are the organs that receive rapidly high levels of drugs

A
  • highly perfused
  • i.e. liver, kidney, GIT, brain, lungs
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Which organs receive lower levels of drugs

A
  • less perfused organs
  • bone, muscle, fat
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Increase in plasma protein binding does what to distribution efficiency

A

Decreases it and its potency

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Acidic drugs bind to

A

Albumin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

When more than 70-80% of a drug is bound to plasma protein, the plasma protein acts as a…

A

Circulating reservoir

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Heavily protein-bound drugs have what kind of plasma half-lives

A

Longer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

If a drug is heavily protein bound, then

A
  • has narrow therapeutic index
  • small vol. of distribution
  • possible toxicity and biological activity of drug increase
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Basic drugs bind to

A

Alpha 1-acid glycoprotein

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Effedcts of plasma-protein binding on drug

A
  • slows rate at which drug reaches a conc. sufficient enough to produce pharm. effect
  • limits glomerular function
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Bleeding syndrome

A

When albumin binds to aspirin instead of warfarin, causing free warfarin to move around in blood

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Barriers to drug dist.

A
  • BBB
  • Placenta
  • Milk
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

BBB as durg barrier

A
  • doesn’t let ionized and non-lipid soluble drugs pass
  • lack fenestrations
  • MDR1 causes more tight junctions
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Placenta as drug barrier

A
  • technically not a barrier
  • highly ionized drugs, low lipid soluble drugs excluded
  • teratogenic drugs
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Milk as drug barrier

Study These Flashcards
A
  • Maximum residue levels in cow milk
  • mammary gland-lipid barrier: drugs easily diffuse from plasma to milk
17
Q

Volume of distribution formula

Study These Flashcards
A

Vd= dose/plasma conc.

18
Q

Volume distribution

Study These Flashcards
A
  • decreased by plasma protein bonding
  • tissue binding increases Vd
Pharmacology
flashcards
Decks in class (20)
# Cards
Brainscape helps you reach your goals faster, through stronger study habits.
© 2026 Bold Learning Solutions. Terms and Conditions