DNA Structure

Question 1

In the DNA of eukaryotic cells, some cytosine bases in 5’ CpG sequences are covalently modified by methylation.

How does DNA methylation arise and what is its key cellular function?

Answer 1

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Question 2

The two strands of the DNA double helix are antiparallel. What is meant by this term?

Answer 2

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Question 3

What are the differences between A-, B- and Z-form DNA?

Answer 3

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Question 4

What is meant by ‘DNA supercoiling’ and how does it arise in cells?

Answer 4

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Question 5

What are telomeres and what is their function?

Answer 5

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Question 6

Describe the main structural features of the DNA helix

Answer 6

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Question 7

Appreciate that the sequence of bases in DNA carries the genetic blueprint of life

Answer 7

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Question 8

Explain how higher order structure is maintained in DNA through nuclear zone for nation

Answer 8

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Question 9

Recognise that some anti-cancer therapies rely on DNA damaging agents

Answer 9

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Question 10

Describe how chemicals and other environmental insults can damage DNA and that cells can respond through their DNA repair system

Answer 10

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