Neurochemistry > Dopamine > Flashcards

Dopamine Flashcards

(7 cards)

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1
Q

Source

A

Tyrosine - L-dopa - dopamine

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2
Q

Rate limiting step

A

Tyrosine hydroxylase

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3
Q

Breakdown enzymes

A

MAO and COMT

MAOB more selectively metabolises dopamine than MAOA

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4
Q

Breakdown product

A

Homovallinic acid

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5
Q

Reuptake

A

Dopamine transporter - cocaine inhibits

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6
Q

Function

A

Motivation
Novelty seeking
Reward circuitry
Arousal
Motor movement in basal ganglia

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7
Q

Receptors

A

All G protein coupled / metabotropic

D1 (postsynaptic) and D5 (limbic) - increase adenylate cyclase

D2, D3, D4 - decrease adenylate cyclase. D4 primarily in frontal cortex ans clozapine has a high affinity

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