Neurochemistry > GABA > Flashcards

GABA Flashcards

(8 cards)

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1
Q

Source

A

Glutamic acid (glutamate)

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2
Q

Rate limiting step

A

Glutamic acid decarboxylase (GAD) catalysis

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3
Q

Synthetic enzymes

A

Glutamic acid decarboxylase (GAD)

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4
Q

Breakdown product

A

Glutamate - succinic acid

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5
Q

Reuptake

A

Into presynaptic nerve terminals and surrounding glial cells

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6
Q

Function

A

Mediates anxiety
Seizure cessation
Actions of benzos, barbiturates, alcohol

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7
Q

Receptors

A

GABA-A - opens chloride channels, inhibitory (leads to hyperpolarisation)

GABA-B - G protein coupled, baclofen is selective agonist

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8
Q

Disorders

A

Role in anxiety disorders and alcoholism
May have a role in epilepsy and Huntington’s

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Neurochemistry
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