Doxycycline

Question 1

Drug Class

Answer 1

Tetracyclines

Question 2

Active

Answer 2

Doxycycline

Question 3

Indications

Answer 3

• Acne
• Malaria prophylaxis
• Respiratory tract infections
• CAP
• Exacerbation of chronic bronchitis
• Acute bacterial sinusitis
• Chronic prostatitis

Question 4

Dose Range

Answer 4

Adult:
200mg on day 1, then 100mg daily (m=200mg/day)

Acne:
50 mg daily for at least 6 weeks

Malaria prophylaxis:
Start taking 2 days before entering, and continue for 2–4 weeks after leaving, an endemic area. Maximum recommended course 6 months.

Question 5

SE’s

Answer 5

• GI upset (n/v, diarrhoea, epigastric burning)
• teeth discolouration
• enamel dysplasia
• photosensitivity
• oesophageal ulcers
• increase in intracranial BP, therefore causes headache
• inhibition of bone growth (in children

Question 6

Counselling

Answer 6

Label: B, D, 4, 8

• Take with food or milk to reduce stomach upset.
• Take with a large glass of water, and remain upright (do not lie down) within 1 hour of taking a tetracycline. This is to stop tablets or capsules sticking on the way to your stomach, and causing painful damage to the lining of your throat.
• Do not take antacids, iron, calcium or zinc supplements within 2 hours of a tetracycline as they may interfere with its absorption.
• Avoid sun exposure, wear protective clothing and use sunscreen while taking this medicine.
• Take a single daily dose in the morning rather than at night.
• May decrease effectiveness of OC ! use barrier methods or abstain.

Malaria prophylaxis (personal measures):
• DEET containing insect repellent
• Clothing that covers most of the body
• Mosquito nets sprayed with permethrin
• Air conditioning

Question 7

Monitoring

Answer 7

n/a