DPS REVIEW

Question 1

Answer 1

Langerhans Cells

• Marrow-derived, dendritic antigen presenting cells
• Clear cells in the suprabasal area
• Folded nucleus, no tonofilaments, desmosomes
• Contains Birbeck granules
• 2 to 4% of the epidermis
• Chronic and repeated exposures to UV depletes LCs

Question 2

Stains for langerhans cells

Answer 2

• S100
• CD1a
• Langerin

Question 3

Identify. What condition is this seen?

Answer 3

Max-Joseph Space

Lichen Planus

Question 4

Identify. What condition is this seen?

Answer 4

Civatte Bodies

Lichen Planus

Question 5

Loss of cell–cell adhesion

Answer 5

Acantholysis, pemphigus vulgaris

Question 6

Answer 6

Anaplasia, Bowen’s disease

Atypical nuclei (abnormal size, shape, staining) and pleomorphism (variation in nuclear characteristics)

Question 7

seen in?

Answer 7

sarcoidosis or berylliosis

• Collections of eosinophilic material seen in sporotrichosis
• Also refers to star-shaped intracytoplasmic inclusions seen in giant cells of sarcoidosis or berylliosis or other granulomatous processes

Question 8

Caterpillar body - Pale pink linear basement membrane material within epidermis

Seen in?

Answer 8

porphyria cutanea tarda

• Represents degenerated type IV collagen

Question 9

Answer 9

Dermatofibroma

Collagen fibers surrounded by histiocytes/spindle cells (collagen balls)

Question 10

Answer 10

Corps ronds/grains, Darier’s disease

• Corps ronds = rounded nucleus with halo of pale to pink dyskeratotic cytoplasm
• Grain = dark blue flattened nucleus surrounded by minimal cytoplasm
• Dyskeratosis = abnormal, individual-cell keratinization

Question 11

Answer 11

Cornoid lamellae, porokeratosis

45° angle parakeratosis in a column above a focus with a diminished granular layer and underlying dyskeratotic cells

Question 12

Answer 12

Epidermotropism

Lymphocytes in epidermis with relative absence of spongiosis: term usually reserved for mycosis fungoides

Question 13

Answer 13

Kamino body

Dull pink to amphophilic basement membrane material within the epidermis in a Spitz nevus

Question 14

Answer 14

Medlar Body
- seen in Chromomycosis

• Brown, round structure resembling overlapping copper pennies
• Divide by septation, resembling a hot-cross bun

Question 15

Answer 15

Pagetoid cells and pagetoid scatter, Paget’s disease

Question 16

Answer 16

Papillary mesenchymal body

Structure that resembles the whorl of plump mesenchymal cells normally present in the hair papilla (seen in trichoblastoma and trichoepithelioma)

Question 17

Answer 17

Shadow cells, pilomatricoma