Droperidol

Question 1

mechanism of action

Answer 1

• acts centrally at sites where DA, NE, 5HT act
• alter CNS transmission
• antiemetic effect at red astrocytes in CRTZ
• moderate alpha-adrenergic blocker
• occupy GABA receptors on postsynaptic membrane -> increase DA within cleft
• neuroleptic anesthesia

Question 2

CV effects

Answer 2

• decrease SVR, MAP
• no change CO, contractility
• prolong QTI -> delayed repolarization -> Torsades

Question 3

Pulmonary effects

Answer 3

minimal

Question 4

CNS effects

Answer 4

unknown

• may worsen extrapyramidal side effects
• contraindicated in Parkinson’s

Question 5

Uses

Answer 5

antiemetic/premed dose 0.625-1.25 mg IV/IM

Question 6

Pharmacokinetics

Answer 6

• onset 5-8 min
• Vd 2.0 L/kg
• duration 3-6 hours
• elim t1/2 1.7-2.2 hours
• hepatic metabolism
• renal/hepatic elim