1
Q
Mechanism of action
A
enhance effects of GABA at GABA(A) receptor with beta3 subunit
2
Q
Time to unconsciousness
A
30-60 sec with rapid awakening
3
Q
Pharmacokinetics
A
- 75% protein bound
- renal/biliary elimination t1/2 75min
- ester hydrolysis to inactive metabolites
- CL 5x that of pentothal
4
Q
CV effects
A
no change SBP, HR, SVR
5
Q
Pulmonary effects
A
minimal resp depression, however increased with opioids
6
Q
CNS effects
A
decreased CBF, ICP, CMRO2
7
Q
Concentration
A
2mg/ml
8
Q
Induction dose
A
0.2-0.4 mg/kg
burns on injection
9
Q
Risks
A
- myoclonus- spontaneous jerking
- adrenal suppression- inhibits 11beta- and 17alpha-hydroxylase -> decrease cortisol/aldosterone
- increase PONV
- NO analgesia
