stages of development
egg&sperm –> fertilization –> cleavage –> gastrulation –> organogenesis –> metamorphosis
cleavage
division of zygote into smaller cells every 12-24 hours
morula
solid ball of cells
blastula
hollow ball of cells
gastrulation
3 germ layers
ectoderm, mesoderm, endoderm
ectoderm
skin, nervous system, teeth, lens
mesoderm
blood, skeletal, muscular, circulatory, and lymphatic system
endoderm
linings of respiratory, excretory, reproductive, and digestive system
deuterosomes
anus first
protostomes
mouth first
differentiation
noggin and chordin
induce mesoderm to change to muscle and notochord (spine)
retinoic acid
regulates limb development and regeneration
homeotic selector genes
lineage map
- allows us to know what cells will become what structures
organogenesis
- apoptosis and gene activation/silencing are very important
apoptosis
hollows out blood vessels, creates fingers and toes, necessary for proper brain development and more
complete metamorphosis
egg larva pupa adult butterfly, mosquito, beetles, frogs
aging
- as we age our cells are less likely to divide and more likely to die
embryonic stem cell retrieval
~100 cells total
blastocyst