Endocrinology

Question 1

What electrolyte abnormalities do you get with diabetes insipidus?

(2)

Answer 1

Hypernatraemia
Hyperkalaemia

Question 2

What electrolyte abnormalities do you get with Bartter syndrome?

(3)

Answer 2

Hypokalaemia
Metabolic alkalosis
Hypercalciuria

Question 3

What is Bartter’s syndrome? (incl. mode of inheritance)

Answer 3

Autosomal-recessive condition leading to tubular defects in sodium-chloride transport and increased intrarenal production of prostaglandin E2 (PGE2)

Question 4

What is Liddle syndrome?

Answer 4

Genetic condition causing early onset severe hypertension characterised by potassium wasting, hypokalaemia and alkalosis, but is associated with low renin and aldosterone production