Characteristics of picornaviridae
- Small
- Non-enveloped
- ssRNA (+)
features of enteroviruses
- stable
- insensitive to detergents
- survive cold and hot temps - Replicate in GIT
- Warm Moist Environments
Types of Viruses under ‘enterovirus’
- Poliovirus
- Coxsackie Virus
- Coxsackie A
- Coxsackie B - Echovirus (Enteric Cytopathic Human Orphan)
- Rhinovirus
Clinical Presentation of Enteroviruses
- Upper Respiratory Tract Infection (normal)
- Hepatitis (complication)
- Meningitis, Encephalitis, Paralysis (complication)
- Myocarditis, Pericarditis (complication)
- Rash, Herpangina, HFMD (normal)
virus isolation for enterovirus
not useful bc slow, better for surveillance as virus takes few days to weeks to replicate
difference between coxsackie A and B
B and echoviruses can be readilky grown in cell culture from throat swabs, feces, rectal swabs, CSF
A cannot be isolated easily in cell culture
A mainly epithelial infection (herpangina, HFMD) vs B muscular (myocarditis)
diagnosis of enterovirus
RT-PCR
Genetic sequencing for typing
enterovirus A71 causes?
Childhood exanthem
HFMD indistinguishable from CA16
might lead to CNS infection (encephalitis)
enterovirus D68 causes
Respiratory Disease Outbreak
what viruses cause HFMD? which causes more severe?
CA16, CA6, CA24, EV71. EV71
