etute4

Question 1

• Valproic acid

Answer 1

Valproic acid has a strong anticonvulsant effect

- Originally Khellin was used to test against convulsion

Question 2

• Acetanilide

Answer 2

• Naphthalene was used to test intestinal worms
• Serendipidously acetanilide was given by mistake and was the actual drug that protects against worms
• Later paracetamol was discovered through acetanilide

Question 3

• Lidocaine

Answer 3

• Extracted from a mutant form of barley
• Isolated a molecule called gramine
• Made tongue go numb
• Lignocaine is the me too drug as it was safer for humans to use

Question 4

• Lithium

Answer 4

• Cade put lithium in a salt soln in water

- Lithium ended up having a calming effect on rats

Question 5

• Minoxidil

Answer 5

• Used initially for blood pressure lowering
• But later found out to be beneficial for bald people
• Known as rogaine

Question 6

• Sildenafil

Answer 6

• Used originally to dilate blood vessels

- Known now as Viagra