Everything Else

Question 1

Answer 1

MCP OA in a young person = think HEMOCHROMATOSIS

Question 2

genotype assoc w/ RA

Answer 2

HLA-DRB1 - confers 4x risk for RA (Class II HLA w/ CD4

citrullinated peptides bind –> QKRAA

Question 3

HLA Class II alleles (DR, DP, DQ) are most strongly assoc w/ what disease?

Answer 3

narcolepsy-cataplexy

Question 4

Wolff’s Law

Answer 4

force applied to bone surface –> bone deposition

force removed –> bone removed

Question 5

longitudinal bone grows by….

Answer 5

endochondral ossification

Question 6

Answer 6

Question 7

lamellar bone grows by….

Answer 7

appositional bone growth

Question 8

Answer 8

osteon and haversian system

Question 9

woven bone in adult

Answer 9

pathological!!

Question 10

mortality one yr after hip fracture

Answer 10

35%

Question 11

fill in table about ages, features, and subgroups of JIA

Answer 11

Question 12

pathogenesis of synovitis (JIA)

Answer 12

• villous hyperplasia of synovium
• hypervascularity
• infiltration of lymph + macrophages

Question 13

sx of JIA

Answer 13

mostly synovitis >>>>>

• joint contracture
• +/- erosions,
• +/- deformity and functional limitations

Question 14

what kind of JIA has a high risk of uveitis?

Answer 14

oligoarticular, ANA+

screen in kids <7 w/ +ANA!!!

Question 15

chilblain’s perniosis

Answer 15

like the venous phase of raynauds.

• venodilation –> pooling of blood in toes and non-specifc inflammation

Question 16

Answer 16

acrocyanosis - normal redistrib of blood flow in a newborn

Question 17

anti-RNP +

Answer 17

assoc w/ mixed connective tissue disease

Question 18

mixed connective tissue disease

Answer 18

• inflammatory arthritis
• raynaud’s
• morphea
• DM or amyopathic DM

Question 19

2 vasculitides in children

Answer 19

• HSP
• Kawasaki’s

Question 20

dx criteria for Kawasaki

Answer 20

Question 21

Answer 21

strawberry tongue in Kawasaki

Question 22

tx for Kawasaki

Answer 22

aspirin and IVIg –> reduces aneurysms to 5%

do echo @ baseline, 3, 7 weeks

continue aspirin for 3wks after last normal echo

Question 23

Answer 23

calcinosis in juvenile dermatomyositis

Question 24

composition of type I collagen

Answer 24

trimer of 2 alpha-1 and 1 alpha-2 monomers

Question 25

pleiotrophy

Answer 25

many effects of a single mutation (in one person's body)

Question 26

genetic heterogeneity

Answer 26

different mutations can cause the same disease

Question 27

variable expression

Answer 27

disease effects of an identical mutations may differ in different people

Question 28

mutations assoc w/ OI

Answer 28

COL1A1 or COL1A2

Question 29

osteomyelitis - histology findings

Answer 29

lots of neutrophils

Question 30

what cancers metastasize to bone

Answer 30

Breast, lung, thyroid, kidney, prostate (BLT w/ kosher pickle)

Question 32

disc herniation

Answer 32

* young pt * normal disc height * radicular pain usually through posterolateral corner of annulus

Question 33

disc degeneration

Answer 33

* middle aged subject * activity related mechanical back pain * referred pain to leg * instability catch

Question 34

spinal stenosis

Answer 34

* elderly pt * neurogenic claudication: standing --\> leg pain w/ chopping cart sign * osteophytes --\> disk narrowing

Question 35

degenerative spondylolisthesis

Answer 35

* middle aged or elderly, esp women * mech back pain + radiculopathy * L4-L5

Question 36

what do fibroblast growth factors do in bone healing?

Answer 36

enhance callus formation: fibrous, cartilage, immature bone

Question 37

what do cytokines do in bone healing?

Answer 37

stimulate bone resorption (esp IL-1)