F1. Fructose.

Question 1

1. metabolism of fructose occurs principally in the?
2. to a lesser extent in the?

the tissues in no. 2 have these two enzymes.

Answer 1

1. LIVER.
2. SMALL INTESTINAL MUCOSA & PROXIMAL EPITHELIUM of RENAL TUBULE.

1. fructokinase
2. aldolase B.

Question 2

1. FRUCTOSE can be synthesized from glucose in the ____ pathway.
2. reduced sugar alcohol: ____ (a) - enzyme: ____ (b)
3. sugar that is oxidized into fructose.

Answer 2

1. polyol.
2. sorbitol (a) - aldose reductase (b)
3. sorbitol

Question 3

• POLYOL pathways is present in?
• synthesize fructose for the seminal fluid

Answer 3

Seminal Vesicles.

Question 4

• use fructose as a major fuel source while in seminal fluid.
• switch to glucose once in the female productive tract.

Answer 4

Spermatozoa.

Question 5

disorders of fructose metabolism

Question 6

disorders of fructose metabolism

• aldolase B deficiency.
• leads to intracellular trapping of F1P.
• a more serious disorder

F1P: fructose 1- phosphate

Answer 6

Hereditary Fructose Intolerance