FA Antibiotics

Question 1

Bind PBPs (transpeptidases).
Block PBP cross-linking of PG.
Activate autolytic enzymes

Answer 1

Penicillin G and V

Question 2

Beta-lactam drugs that inhibit cell wall synthesis, but are less susceptible to penicillinases. Bactericidal

Answer 2

Cephalosporins

Question 3

A monobactam; resistant to beta-lactamases. Prevents peptidoglycan cross-linkign by bind to PBP 3. Synergistic with aminoglycosides. No cross-allergenicity with PCNs.

Answer 3

Aztreonam

Question 4

Broad-spectrumm, beta-lactamase-resistant carbapenem. Always administered with cilastin (inhibitor of renal dyhydropeptidase I) to decrease inactivation of drug in renal tubules.

Answer 4

Imipenem (carbapenem)

Question 5

Inhibits cell wall peptidoglycan formation by bind D-ala-D-ala portion of cell wall precursors. bactericidal.

Answer 5

Vanco