acetaminophen brand name
tylenol
acetaminophen adult + pediatric dosing + max dose
adult: 325- 1000mg IR q4-6hr; 650- 1300mg ER q8hrs
Max: 4000mg/day
Pediatric: 10-15mg/kg q4-6hr
max: 5 doses in 24 hours
acetaminophen class + MOA
class: antipyretic, analgesic: central inhibition of prostaglandin synthesis (PGE2 for fever)
acetaminophen sx that will be treated
1st line therapy for fever discomfort
mild to moderate headache pain
acetaminophen onset of action
30 min- 1 hr with reduction in fever by 1-2 degrees
max temp reduction at 2 hours
acetaminophen side effects
none
acetaminophen pregnancy and breastfeeding parameters
safe
acetaminophen should be used in a lower dose (2g/day) in what populations (4)
ibuprofen brand name
motrin, advil
ibuprofen adult + pediatric + max dose
adult: 200- 400mg q6-8hr
max: 1200mg/day
pediatric: 5- 10 mg/kg q6-8hr
max: 4 doses/24hrs
ibuprofen low dose vs. high dose
low: reduce pain/ fever
high: inflammation/ high fever
ibuprofen class + MOA
NSAID/ analgesic/ antipyretic/ anti- inflammatory: inhibits COX-1 and COX- 2 centrally and peripherally to reduce prostaglandin synthesis (PGE2 for fever)
ibuprofen sx that will be treated
1st line for fever discomfort (may be more effective than APAP)
mild to moderate headache pain
ibuprofen onset of action
30 min- 1hr with reductions in fever by 1-2 degrees. max temp reduction at 2 hours
ibuprofen side effects (7)
ibuprofen DI
warfarin, lithium, drugs that increase risk of bleednig
ibuprofen pregnancy and breastfeeding parameters
caution after 20 weeks, avoid after 30 weeks
avoid in breastfeeding
ibuprofen age restriction
> 6months
ibuprofen CI
patients with ASA allergy
ibuprofen caution in populations (5)
Naproxen brand name
aleve
Naproxen onset of action
30-60 min
Naproxen age restirction
> 12 yrs
Naproxen dosing + max
dosing: initial 440mg followed by 220mg q8-12hrs
max: 660mg/ day