Final Exam

Question 1

Suztrigine

Answer 1

the first non-opioid analgesic
binds to the Na 1.8 sodium channel and blocks action protentional from firing

electrical stimulation voltage ion probe reader (fancy assay)

Question 2

Phizer’s Abrocitinb (Clibinqo)

Answer 2

Atopic Dermatitis

Binds to JAK1 ATP site and inhibits inflammation markers IL31 & CRP

intense pptx

Question 3

Risdiplam (eversdi)

Answer 3

Spinal Muscular Atrophy (SMA)

Mismatch repair through binding to the 5’ splice site (RNA BS)

strengthening the splice to include exon 7 will produce finctional SMN protein
Liquid or pill

Question 4

Sotorasib (Lumakras)

Answer 4

non-small cell lung cancer

inhibits the mutated KRAS G12c protein through an irreversible covalent bond

avoid co-adiministartion with strong CYP3A4 inducers

Question 5

Cobenfy (xanomeline & trospium chloride)

Answer 5

schizophrenia

activates muscarinic M1 and M4 receptors

xanomeline - can cross BBB (isolated from acrea nut)
trospium chloride - cannot cross BBB (isolated from atropa belladonna)

Question 6

Epidiolex (cannnabidiol)

Answer 6

seizures

not fully known but is an agonist against human TRPV1

add on for Dravet Syndrome (DS) and Lennox-Gastaut Syndrome (LGS) therapies

Question 7

Ventoclax

Answer 7

blood caner (leukemia)

Blocks BCL-2 family protein-protein interactions

bioavailablility increases when taken after eating

Question 8

Dasiglucagon

Answer 8

hypoglycemia

binds to glucagon receptor with activated cAMP so liver breaks down stored glucagon which increases blood levels

injection
Normoglycemic rats
insulin induced hypoglycemic rates

Question 9

Velsipity (estrasimod) !!

Answer 9

ulcerative colitis

sphingosine 1-phosphate (S1P) receptor modulator

regulates the movement of lymphocytes

Question 10

Entrectinib (Rozlytrek)

Answer 10

non-small cell Lung Cancer

inhibition of several receptors tyrosine kinases that are rendered constitutively active by gene fusion from the ROS1

can cross blood brain barrier
can be sprinkled on food

Question 11

Rmibrutinib/Rhapsido!!

Answer 11

Chronic Spontaneous Urticaria

Selective burton tyrosine kinase inhibitor

effects more women then men

Question 12

Rinvoq Upadacitinib

Answer 12

Inflammatory Diseases (Rheumatoid Arthritis)

ATP competitive JAK inhibitor

don’t drink grapefruit juice when taking rinvoq

Question 13

Solarimeter

Answer 13

Narcolepsy % Sleep

dopamine and norepinephrine reuptake inhibitor