Johnson: PK2 Flashcards by Megan Dillman

Q

when the does is higher Vd will

A

not change

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Q

in linear kinetics as time passes after drug administration Cl, Kel, or Vd will

A

not change

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Q

In non-linear kinetics where does it saturate

A

ADME

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Q

pros of oral administration

A

convenient
cheap

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Q

cons of oral administration

A

oral adsorption may be incomplete
first pass drug loss maybe incomplete
difficulty in achieving precise control of the plasma concentration-time profile

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Q

what is bioavailability

A

it is the fraction of the does that reaches the systemic circulation (the heart)

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Q

how to you determine the abs. bioavailability

A

it can be calculated by the dosage relative to the administration route

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