GI 22

Question 1

What prevents the stomach from digesting itself?

Answer 1

• Alkaline bicarbonate mucus
• Tight junctions
• High turnover of cells

Question 2

What can breakdown of the gastric epithelium cause?

Answer 2

The formation of ulcers

Question 3

Which bacteria causes stomach ulcers?

Answer 3

Helicobacter Pylori

Question 4

What are the ways stomach ulcers can be diagnosed?

Answer 4

• Medical history & physical exam
• Laboratory test for H. Pylori infection
• Endoscopy
• Barium meal x-ray

Question 5

What is the treatment for ulcers?

Answer 5

• Antibiotics
• Antacid
• Inhibition of stomach acid

Question 6

What are the two ways stomach acid can be inhibited?

Answer 6

• Histamine blockers - Block specific histamine receptors found on parietal cells
• Proton pump inhibitors - Direct inhibit proton potassium ATPase on the membrane of parietal cells that secrete protons into the stomach