GI Pathology

Question 1

pathophys celiac dz

Answer 1

• gluten enteropathy
• intestinal inflammatory disorder triggered by a protein in wheat, rye, and barley
• inflammatory response > damage to intestinal epithelial cells > inability to absorb other nutrients

gluten = gliadin and glutenin in wheat and secalin in barley and rye (all rich in AA proline and glutamine); resistant to complete digestion by pepsin and pancreatic proteases