Hepatitis B Serologic Tests

Question 1

Interpret the following results:

HBsAG = negative
anti-HBc = negative
anti-HBs = negative

Answer 1

susceptible

Question 2

Interpret the following results:

HBsAG = negative
anti-HBc = negative
anti-HBs = positive > 10 mIU/mL

Answer 2

immune due to vaccination

Question 3

Interpret the following results:

HBsAG = negative
anti-HBc = positive
anti-HBs = positive

Answer 3

immune due to natural infection

Question 4

Interpret the following results:

HBsAG = positive
anti-HBc = positive
igM anti-HBc = positive
anti-HBs = negative

Answer 4

acutely infected

Question 5

Interpret the following results:

HBsAG = positive
anti-HBc = positive
igM anti-HBc = negative
anti-HBs = negative or positive

Answer 5

chronically infected

Question 6

Interpret the following results:

HBsAG = negative
anti-HBc = positive
anti-HBs = negative

Answer 6

4 interpretations possible

1. may be recovering from acute infection
2. may be distantly immune
3. may be susceptible with a false positive
4. may be chronically infected