Mechanisms
Increased intake or absorption
-Transcellular shifting
-Decreased renal excretion
-Multifactorial
Increased intake
-High P diets
-Administration of P compounds
-Hypervitaminosis D
Transcellular shifting
-Acute tumor lysis -> release intracellular contents
-Severe soft tissue trauma-> release contents
Decreased urinary excretion
-Decreased GFR
-Urinary bladder rupture
-Decreased PTH
Neonates and young
-Increased GH-> increases vitamin D, increased resorption
-Bone growth
Acromegaly
Increased GH-> increases vit D and increased renal reabsorption of P