ICPP

Question 1

What is Multiple Sclerosis and why does it occur?

Answer 1

• This is a disease of the immune system where myelin is destroyed in certain areas of the CNS.
• Problems with conducting action potentials - decreased conduction velocity, complete block or cases where only some action potentials are transmitted.

Question 2

What does the drug D-Tubocurarine do?

Answer 2

Competitively blocks nACh receptors - causes paralysis as action potentials can’t be produced and muscles can’t contract

Question 3

What does succinylcholine do?

Answer 3

Inactivated Na+ channels adjacent to neuromuscular junction - block depolarisation and therefore muscle contraction

Question 4

What is Myesthenia Gravis?

What are the signs/symptoms?

Answer 4

• Autoimmune disease targeting nACh receptors.
• Endplate potentials are reduced in amplitude leading to muscle
  weakness and fatigue
• Patients suffer profound weakness that deteriorates with exercise