Immune modulators

Question 1

T and B-cell Suppressors

MOA-

Answer 1

Block antibody production by B cells, inhibit suppressor and helper T cells, and modify the release of interleukins and of T cell growth factor

Question 2

T and B cell suppressors

Names-

Answer 2

• Cyclosporine (P)
• Azathioprine
• Glatiramer
• Mycophenolate
• Tacrolimus

Question 3

T and B cell suppressors

Cyclosporine-

Answer 3

(P) Suppression of rejection in a variety of transplants, RA, and psoriasis

Question 4

T and B cell suppressors

Azathioprine-

Answer 4

Prevention of rejection in renal hemotransplants and tx of RA

Question 5

T and B cell suppressors

Glatiramer-

Answer 5

Reduction of number of relapses in MS in adults

Question 6

T and B cell suppressors

Mycophenolate-

Answer 6

Prevention of rejection after renal or heart transplants in adults

Question 7

T and B cell suppressors

Tacrolimus-

Answer 7

Prevention of rejection after heart or liver transplants

Question 8

T and B cell suppressors

Contraindications-

Answer 8

• Known allergy
• Preg/Lact
• Hepatic dz

Question 9

T and B cell suppressors

Adverse effects-

Answer 9

• Increased risk for infection
• Development of neoplasms
• Hepatotoxicity
• Renal toxicity/ dysfxn
• Pulmonary edema

Question 10

T and B cell suppressors

Drug-Drug

Answer 10

Increased risk of toxicity if these drugs are combined with other drugs that are hepatotoxicity or nephrotoxicity