Interleukins

Question 1

Interleukins-

Types of preparations-

Answer 1

Aldesleukin (P)-
Human interleukin produced by recombinant DNA technology using e. coli bacteria

Oprelvekin-
A newer gent produced by DNA technology

Question 2

Interleukins-

MOA

Answer 2

• Increase the number of natural killer cells (NK cells) and lymphocytes
• Activates cellular immunity and inhibits tumor growth

Question 3

Interleukins-

Indications

Answer 3

Aldesleukin(P): Specific renal carcinomas, possible tx of AIDS and AIDS related d/o’s

Oprelvekin: Prevention of severe thrombocytopenia after myelosuppressive chemotherapy

Question 4

Interleukins-

Contraindications

Answer 4

Known allergy, preg/lact.

Question 5

Interleukins-

Cautions

Answer 5

Renal, liver, or cardiovascular impairment

Question 6

Interleukins-

Adverse effects

Answer 6

• Lethargy
• Myalgia
• Arthralgia
• Fever
• Resp. difficulties
• depression with suicidal ideation